I'd very much like to see a remake or return to the Blood Omen style of Kain games. That game, in its day, was like a splash of cold water to me after eating up every RPG I could find. I liked the unrelenting nature of that world, just how committed it was to its decay and bleak nature. And that ending... mmm.
@zombiepie: ZP knows this but I have the complete opposite feelings. I think Sopranos's earliest seasons are a masterclass in intense character studies and family drama, while the last three seasons lose a lot of the show's special flavor in favor of a more realistic tone and a limp ending far removed from the meaty satisfaction of those early seasons.
Practically every PS1 and PS2 RPG that hasn't been ported. Thinking Xenosaga, Suikoden (to modern consoles on a digitally sustainable store), WILD Arms (and Alter F, now that I think about it), all those.
I'm one of those odd ducks who thinks the worst part about Metal Gear was Kojima's lack of an editor, so assuming this isn't another franchise cash-in, sure, why not? (Edit: I think I stole that editor line from Zombie_Pie. Still true!)