I've never understood the point of Vignetting other than to obscure parts of the screen. Most of the time, it's just annoying but sometimes it actually hurts my eyes. This was most recently a problem in Dishonored 2 where I had to spend several hours before I could deal with it. My eyes felt like they were swimming. The usual trick of increasing FOV didn't help either.
Other than that, I'm not a fan of motion blur but it never really affects the way I play, it just looks bad. All the other stuff up there I like a lot.
Usually, I try to keep as many things on as possible in order to see the game the way the developers intended.
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