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Leader of a gang of psychos who hide out in Skag Gully, 9 Toes is the first boss encounter in Borderlands. In addition to the deformity which gives him his name, he has three balls.
Adam the Clown is a psychopathic killer dressed as a clown who dual-wields mini chainsaws in Dead Rising.
As the leader of the Nazis, Adolf Hitler has appeared as an antagonist in several video games. Commonly considered the worst person ever, if you get the chance to kill him, you probably should.
A retired doctor whom Madison encounters.
The master assassin who killed Namira's family and enslaved her. Now working for The Seven.
Albedo is a pivotal character in the Xenosaga universe and the main antagonist of Xenosaga 2.
Albert Contiello is one of the 'psychopath' boss characters that appears in Dead Rising 3.
A traitor and enemy to the vast majority of Resident Evil's protagonists, Albert Wesker has rapidly achieved super-villain status within the series canon.
The elderly telekinetic villain of inFamous and the leader of the Dust Men.
Victim of Jigsaw in the Saw franchise. Later she accompanies him in "helping" other people.
Andrew Ryan is the founder of Rapture, the undersea Utopia that is the setting for BioShock. His name is a partial anagram of Ayn Rand, author of the novel Atlas Shrugged, which served as the main inspiration for Ryan's philosophies and aspects of BioShock's story.
A cybernetically enhanced super agent working for UNATCO in the original Deus Ex game. Begins as your ally and eventually becomes an adversary.
A crazy psychopathic chef that can be round in Dead Rising 2.
A psychopathic character in D4. He possesses information that is highly valuable to David.
The main antagonist of For Honor's Story Mode, she is the leader of the Blackstone Legion and strives to bring endless war to the lands.
Once a warrior of Sigmar, now the current champion of Chaos Undivided, Archaon strives to bring about the End Times to the Warhammer Fantasy world. Despite this, he secretly loathes and plots against the Chaos Gods.
The Everchosen who preceded Archaon, his death marked the end of the Great War Against Chaos
Astaroth is a golem spawn created by the grand priest of the cult Fygul Cestemus. He seeks the Soul Edge for his master.
The cunning, intelligent, and ruthless arch-enemy of Andrew Ryan, and the leader of the opposition in the power struggle which led to Rapture's collapse.
A bounty hunter of the Star Wars universe. A former Jedi in the Legends continuity.
A leader of the Orcs. He was portrayed by Manu Bennett in The Hobbit film trilogy.
The twelfth Baron Zemo of Germany, and father of the better-known Helmut Zemo.
Mercenary enemy of the Punisher.
Known as both the First Damned and the Dark Master, Be'lakor was the very first mortal to ascend to Daemonhood, but was passed up by the four Chaos Gods as a candidate for the Everchosen. Nevertheless, he is a proud follower of Chaos.
Blood-thirsty and a fiercely loyal servant to Lord Voldemort, Bellatrix Lestrange is a deranged, deadly witch.
Bergan is the Judge Magister of the Archadian Imperial Army and director of the 2nd Bureau. The strongest of the Judges due to the manufacted Nethicite that he carries with him.
A psychopath from Dead Rising 2, willing to perform for any audience, even if they are zombies.
A psychopath in Dead Rising 2.
Black Manta was a young boy with autism who was thrown in Arkham Asylum because his parnets believed he was crazy, he later became an enemy of Aquaman and occasionally Batman
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