R.B.I. Baseball 4 is the fourth game in Atari/Tengen's series of baseball simulators, which originally began as a reskin of Namco's Family Stadium franchise. It is the first game in the series to be released solely for 16-bit systems, and the first to be Sega Genesis exclusive. Subsequent entries would use the release year instead, with the next game being R.B.I. Baseball '93.
Notably, this was the first game in the series to see a Japanese localization, however that version does not use its equivalent Nippon Professional Baseball license. A Sega CD port was in development but was cancelled partway through.
Included with the new features introduced to R.B.I. Baseball 4 are a Home Run Derby mode and a mode called Game Breakers, where the player is placed in a demanding hypothetical scenario and must figure out how best to proceed.