GTA on horses
I loved GTA, all of them, each one bringing something new to the series or refining existing elements. While Red Dead lacks some of the better elements of recent GTA games, for example the social interactions between characters, it brings it's own little touches to the table, starting with one of, if not the best main character in a GTA game to date, we all loved Niko Bellic,or most did, but most will like John Marston much better. On top of that it takes the action away from Liberty City which, while very well detailed, was often too big for it's own good, and gives you a much larger but more open area to play in. As well as a fairly length and well written story campaign the game features various side-quests, amusements and of course a decent multiplayer.
Perhaps my only negative point about the game is that the fun amusements like Poker, Blackjack etc really should have made it into the multiplayer free-roam and would have been an amazing addition.
If you liked GTA you'll probably love Red Dead Redemption, if you hated GTA you'll probably hate Red Dead Redemption.