well weskers died so whos left to carry the torch of umbrella?  
 
also what is left, for them to make resident evil 6? 

It doesn't really matter since RE6 will be a reboot anywhoo, but there's still Nicholai left in regards to the remaining RE villains.  
 
Plus RE Revelations looks to have HUNK factor some more into the story aswell, if any of that will be considered canon. 
 
  

Nobody ever truly dies in these games. 
 
Also, spoilers...

whats so bad about this nicolie guy?

To turn it into a generic class based third person shooter that emphasizes online play.

" whats so bad about this nicolie guy? "

Point and click adventure game^^

ah i see he' controls the bows 
 
i hope the last one will be with Chris and Kennedy teaming up. 
Would be so awsome

I would rather like a reboot. 
The main story ended nicely in RE5, and one of RE biggest problems was coming to conclusions with it's fiction. It went on way too long. Wesker was the bad guy who's thread connected the entire series, his final battle with Chris was an excellent way to end the series, or at least the main plot-thread. His plans are destroyed, Umbrella is destroyed, and now Chris and company can finally rest easy.
 
Either retell the story with more coherency, or do something drastically different. The idea of making a RE6 in the same universe with Wesker coming back from the dead like a comic-book villain doesn't seem appealing to me at all. Yeah, he "died" and resurrected in the first game, but that was the synapse of his origin to becoming the villain we all now and love. He died in a fucking volcano in the fifth game (>Insert Tekken 2 joke here<). 
Make it permanent.

Next is a multiplayer focused game made by slant six!!!! (apparently). They totally didn't destroy socom or anything, i can't see what could possibly go wrong with this next game.

well they could make a game with Kennedy and   Nicholai

RE4 HD

Probally another game with leon s. kenedy as the protagonist.

There's still the mysterious Organization. So far they have collected every single virus made by umbrella and both the standard and control plagas, I doubt they're just gonna sit on their @sses with all these biological weapons.

what about ada we still don't know much about her. 

How about somebody else takes over writing the fiction for that game. Reboot that shit, let them make the actual game again, but for fucks sake the last half of that game was god damned insane. Don't get me wrong, I enjoyed the game and beat it, but come on.