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Spider-Man's beloved aunt, May Parker.
Black Cat is a sometimes burglar, sometimes hero, friend and former lover of Spider-Man. She gains her abilities from a combination of magic and science.
In the Spider-Man movie universe, Bonesaw was Spider-Man's wrestling opponent, before Peter Parker became a super hero.
Doctor Otto Octavius was a scientist who turned to a life of crime, using a set of four flexible mechanical arms originally designed to assist in scientific research and labwork to give himself a major advantage over the police.
Eddie Brock is a character in the Marvel Universe best known as Venom. He became Venom when he joined with an alien symbiote life form and was one of the most fearsome enemies of Spider-Man. He has also use the Anti-Venom and Toxin symbiotes at different points in his life.
The Green Goblin is Norman Osborn, a businessman and scientist who injected himself with an experimental serum to test it. The serum granted him immense strength, but also drove him insane. He is considered the arch nemesis of Spiderman. He is known for using his glider and pumpkin bombs.
One of Spider-Man's first girlfriends. In some universes, she is also known as Spider-Gwen. She has been portrayed by Bryce Dallas Howard, Emma Stone and Hailee Steinfeld in various films.
Harry Osborn was Peter Parker's best friend. He became the second Green Goblin after finding out Peter Parker was Spider-Man, who he thought was responsible for his father's death.
The editor-in-chief of the Daily Bugle in Spider-Man games. Has an agenda against the wall-crawler. He is portrayed by J.K. Simmons in the Sam Raimi Spider-Man Trilogy and the Marvel Cinematic Universe.
The Kingpin, aka Wilson Fisk, is the biggest crime lord in New York City, and possibly the world. He operates under the guise of a legitimate businessman and philanthropist, much to the chagrin of Spider-Man, Daredevil, and the Punisher.
Kraven, the world's greatest hunter, is obsessed with killing Spider-Man, whom he views as the ultimate prey.
Dr. Curt Connors is a scientist in the Marvel Universe who transforms into the vile Lizard, usually fighting Spider-Man.
Love interest of Peter Parker (aka Spider-Man). Her bright red hair is iconic.
Morbius was born with a rare blood disorder. In an attempt to treat himself he was transformed into a living vampire. He has been both a force of good and evil in his time. He is portrayed by Jared Leto in Sony's Marvel Universe.
Mysterio is a villain from Marvel Comics. He is specifically Spider-Man's enemy. He is recognized by his large fishbowl helmet and his use of illusion. He was portrayed by Jake Gyllenhaal in Spider-Man: Far From Home (2019).
Rhino is a nemesis of Spider-Man. His costume gives him superhuman durability and strength.
The Sandman, also known as Flint Marko or William Baker, is a Marvel Comics character and a regular enemy of Spider-Man. He has occasionally been a superhero, and even briefly was a reserve member of the Avengers.
Scorpion is a nemesis of Spider-Man. He was once private investigator Mac Gargan, until J. Jonah Jameson hired him to be the subject of an experiment that gave him immense strength, a costume with a tail that fires lasers, and the deep-down crazies. He was the third Venom.
With a terrible track record, a costume resembling a soiled mattress, and a name that inspires fear for all the wrong reasons, the Shocker is primarily a laughingstock. This Spider-Man villain has gauntlets that allow him to generate powerful shockwaves.
After being bitten by a radioactive spider during a science exhibit unrelated to school, timid teenager Peter Parker becomes the Amazing Spider-Man. Armed with the ability to climb walls and enhanced strength, Spider-Man uses his powers to fight evil and protect the innocent.
Vulture is a villain in Marvel Comic's Spider-Man Series. Adrian Toomes created the flight suit and became the Vulture.
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