Agents are superhumans designed by the Agency using the previous work of disgraced scientist Dr. Baltazar Czernenko. Agents were originally designed to fight against crime. The Agents are the playable protagonists throughout the Crackdown series.
After the Agency was pushed back by the enemy gangs in Crackdown, they started to realize drastic measures had to be taken to regain the upper hand in Pacific City. Dr. Baltazar Czernenko was in charge of the creation of The Agents. After he concieved the first Agent, the cloning process made sure there would never be a shortage of Agents. Dr. Baltazar Czernenko left The Agency, and started working for the Shai-Gen Corporation. Because he left The Agency, he had to start over. These failed attempts resulted in the creation of Freaks in the original Crackdown.
- The default African American Agent's design in the original Crackdown was inspired by the comic book character Blade.
- Crackdown's Agents are similar to the supersoldiers in the Prototype series.