Toxic Crusaders is a beat 'em up / shoot 'em up platformer made for the NES, Game Boy, and Sega Genesis; respectively developed by TOSE, Realtime Associates, and Infogrames. The Nintendo versions were published by Bandai and Sega handled the publishing for the Genesis. The game was based on the short-lived animated series that shares the same name, which itself was a kid-friendly take on The Toxic Avenger film made by Troma Entertainment.
The game sees the player take control of the protagonist Toxie and play six different levels, fighting off enemies with Toxie's mop. The game begins in Tromaville, fighting the Radiation Rangers, before traveling through different locations such as on top of a train or inside an alien spaceship. The final stage of the game takes place in the palace of the antagonist, Czar Zoster.