Uncharted 3's got rid of Chloe and Talbot in a very subtle and anticlimactic way, but Uncharted 2's plot is inane at spots.

Carrying Jeff when the group is being showered with bullets is probably the most stupid part of all Uncharted games. It was a lousy decision, that lead to an unbelievably bad development in the story. In real life Drake would have died 10 times in the space of that segment. There is no suspension of disbelief that can save the story at that part. And going after a fellow treasure hunter that betrayed Drake and delivered him to the wolves, is another arguably stupid decision.

Uncharted 3 had plot holes, but Uncharted 2's story is on a whole another level of fiction.