I remember on an old Bombcast that Jeff explain his house rules for Uno where they said "fuck you" for something specific happening.  Does anyone remember which podcast he said it or what the rules were?  Or maybe Jeff, you could elaborate on this yourself perhaps?

When you lose you strip and expose your self over your xbox camera. 

Looks like this is the right one. I haven't listened to it yet, but the description looks promising.
 
 http://www.giantbomb.com/podcast/?podcast_id=53

1. For starters, this is UNO for money and all money must be kept in your sock. If you're not wearing socks, you have to put on socks.
2. The Zeros do bad things. Any time you play it, you have to say "Fuck you" to the other player.
3. The other player can either draw 8 (cards) or counter by playing two Zeros and saying "No, fuck YOU."
4. At which point the final counter to that is a Green Zero. You lay it down last and say "No. Fuck. YOU." (Automatically win and collect all money from all socks.)