Part of Nintendo's pitch for Wii U at E3 this year was the new appeal its new console would have for the kinds of players who felt pushed to the outskirts during Wii's mainstream popularity. Nintendo's focus had been on making hits in the vein of Wii Sports, not Metroid Prime.
Having BioShock designer Ken Levine appear in a promotional video at Nintendo's press conference, discussing the possibilities of Wii U, certainly suggested a new direction was possible.
In an interview with IGN, however, Levine made it clear that his excitement for what's possible on Wii U doesn't mean his studio, Irrational Games, has already started working on anything for Wii U.
"Just to be clear, there are no plans," said Levine. "I'm not saying it can't happen, but we have no plans to do any games for that platform."
BioShock Infinite is scheduled for a vague "2012" release. The original BioShock had a surprisingly great release in August, a month that's found repeatable success in launching games (like Batman: Arkham Asylum) that might otherwise have trouble fighting through the noise of Call of Duty and other established franchises releasing around Christmas. Nintendo has not committed to a release date for Wii U, either, only saying the hardware will launch after April 2012.
There's time for BioShock Infinite to find its way onto Wii U, but it's also not a surprise that Levine's remaining noncommittal.