Did anyone have problems with a particular boss throughout the game?
 
I have to say encountering Sister Grim for the first time was nuts, I did thought of hurting her weak spots the first time then it was just impossible.
Her chest....I thought it was red, till.........Till I had to use flames on that dodging bitch.
 
What about everyone else's encounters with these bosses?
 
(I'm not looking forward to the hard difficulty, expecially the few last chapters O.O)

I thought all the bosses were easy, the only part that I had to re-do a lot is when Paula chases you. One wrong step and she latches on to you.

I hated the final boss fight with Paula. That one demon that she lets loose kept getting in my way and knocking me back into the darkness. I didn't fail, but it was fucking annoying.
All of the bosses were quite easy, though, especially against Fleming.

George in Beast Form, which is weird 'cause George in Human Form is my favorite boss,. but geez, it's hard and annoying to shoot  Beats George's back. I had fun with the other ones(Except Fleming. The Battle was cool, but too long. Oh, and Stinky Crow.) and, i loved the battle against Paula, it was pretty awesome.

I hate a lot of fun with all the bosses.  The only one that gave me serious trouble was the second grim reaper when she split into like a dozen forms.  
 
I thought the bosses were really fun.  There was some worry going in about how predictable glowing red spots were, but I found that figuring how how to expose the glowing red spots were challenge enough.

I hate a lot of fun with all the bosses.  The only one that gave me serious trouble was the second grim reaper when she split into like a dozen forms.

Re: Second Grim reaper boss - Luck plays a big part of it, but I found that dropping finesse, and just going mental with the light shot was the best bet.  If I got hit or lost my rhythm, I know it would regroup and split into a dozen again before I could get most of them, so I would retreat to the goat head, health up, and try again.  Eventually, luck will stricke and one of the first few you hit will end up being her. 
 
Re: Paula chases - I agree that these are a pain in the ass, and that the controls are much to sluggish to handle what you're expected to do.  I love the set piece of it all; I just wish they did it differently.  I think zombie Paula is the only truly frightening creature in the whole game.  For the part where you had to run AND fight dudes, I had my boner ready from the start.  Run - bomb the tree - quick turn - light shot her (this stuns her) - quick turn back - run - switch to shot gun - run and gun the two baddies (you should be able to one shot them both). 
 
The last time you encounter her is the worst.  In the catacombs when she is facing you in a thin corridor.  You can light shoot her to go around her, but the controls are so sluggish, she can snap out of it before you even get a good pace going.  Actually, because it's so hard to run AND go around her quickly, I just ran straight into her about 5 times (you still die if you touch her when she is light-stunned).  And yeah, she would kill me in the oddest places.  Garcia would fall back and clip through walls like a mofo.  It just pissed me off more that I kept losing, as well it looking broken and stupid.  
 
The reaper gave me trouble, but didn't make me angry.  Paula did, and so did the big boner sequence (reminded me of the asteroid shooting in Dead Space).  The entire rest of the game I enjoyed thoroughly.

All the bosses were fun actually, survived through all of them... except for the 2nd Sister.  I HATED that fight so much, was there an actual way to fight her?  The way I figured out which one was the real one was by spraying with the Teether, then nothing which one didn't flicker when I shot at her, then shot a light shot.

I hated the Justine fight because it felt like I was cheated out of a better fight

They were all pretty fun though really easy.

The only thing that I had to redo a lot was the Paula chase sequences. Then I remembered you can sprint, and I was good to go!

The Paula fight, when you're in between the dark points. Couldn't lock onto her with Dentist, because the dark demon kept hitting me, and couldn't kill him because he's always stay right in front of the dark, so when I lit him up, he just got dark again. 

Not a boss fight, per se, but near the end of the game the enemies with the red syringes, I guess, on their backs?  They were the most problematic enemy for me, by far.  All I could figure to do was lock on with The Dentist and let loose the entire payload for it, but even then I'd have to switch to the Hot Boner or the SkullBlaster and hope I didn't run out of ammo for that, too.
 
All of the boss fights were pretty easy, though.  I guess the most trouble I ran into was George's beast form, but it still wasn't difficult.

All easy.

I had an easy time beating all the bosses even on harder difficulties.

They were all pretty piss easy, but I liked their gameplay overall.

The only one I really had an issue with the George. Other than that the game wasn't too hard, but I loved all of it. Easily one of my top 5 of the year.

Fleming was the only one that gave me a problem.

@King_Bonzo:  AHhh yes that was a pain but you have fully charge the green skull bomb on him there is a hole above him. That is the only way to take him down, and of course that green barrier was a huge pain for the fight.

Fuck me side ways there is NOT ENOUGH TIME between his crack turning yellow and him recovering in order for me to hit him with the hot boner. Not. Enough. Fuck. Ing. Time. 
 
Any one beat him on Legion I need some serious help. My current tactic on the third stage of fleming is to stun him out of his green shield, 
 unload my dentist into him which sometimes turns him yellow, sometimes it doesn't, but when it does I switch to the boner charge the shot and one of two things happens: 
 
1) the shot is on target but for some reason doesn't stick. 
2) it sticks but he instantly recovers 
 
I am "this close" to selling this game. Shame cause I've loved it up until now.