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In the Marvel Universe, Carl Burbank is a former CIA agent whose arm can transform into an organic gun. Known for a false sense of piety, a hatred of mutants and a deep appreciation of art, Buckwacker is most commonly associated with the Punisher and Daredevil.
Count Luchino Nefaria is an "ionic vampire" super-villain.
A former member of the Serpent Society, Diamondback was once Captain America's lover.
Francine Frye was an obsessive supervillain fangirl who became the second Electro.
The Sandman, also known as Flint Marko or William Baker, is a Marvel Comics character and a regular enemy of Spider-Man. He has occasionally been a superhero, and even briefly was a reserve member of the Avengers.
The Hobgoblin is a Spider-Man villain. Roderick Kingsley, a fashion designer with connections to the criminal underworld, became the Hobgoblin when he discovered a cache of weapons and a glider left by the Green Goblin.
The Kingpin, aka Wilson Fisk, is the biggest crime lord in New York City, and possibly the world. He operates under the guise of a legitimate businessman and philanthropist, much to the chagrin of Spider-Man, Daredevil, and the Punisher.
Scorpion is a nemesis of Spider-Man. He was once private investigator Mac Gargan, until J. Jonah Jameson hired him to be the subject of an experiment that gave him immense strength, a costume with a tail that fires lasers, and the deep-down crazies. He was the third Venom.
After Quentin Beck went missing, his Mysterio gear was auctioned off to a random criminal, who began calling himself Mysterion.
The Green Goblin is Norman Osborn, a businessman and scientist who injected himself with an experimental serum to test it. The serum granted him immense strength, but also drove him insane. He is considered the arch nemesis of Spiderman. He is known for using his glider and pumpkin bombs.
Doctor Otto Octavius was a scientist who turned to a life of crime, using a set of four flexible mechanical arms originally designed to assist in scientific research and labwork to give himself a major advantage over the police.
Teams up with Spidey in Spider-Man: Friend or Foe (PSP version)
With a terrible track record, a costume resembling a soiled mattress, and a name that inspires fear for all the wrong reasons, the Shocker is primarily a laughingstock. This Spider-Man villain has gauntlets that allow him to generate powerful shockwaves.
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