@chibithor: I would agree that Dota 2 definitely has a wider area for expansion, but @canteu makes a good point in that LoL is much more manageable for balance. Now, there are champions with their own unique mechanics that have no similarities, yes. I mean, even in Dota 2, there are many cases where 2 characters have a ridiculously similar move. For example, both Nyx Assassin and Lion have a very similar Earth Spike.
To get to your question, I'd say that there are a few champions that play wildly different from the rest of the LoL champion pool. For example, half of Heimerdinger's damage comes straight from 2 turrets he places on the ground that attack in an aoe around themselves. Therefore, a good Heimer does not run to the nearest safe building like most champions. He kites around his turrets until the other champion murders himself. Another example would be Zed, who works on an energy system. Think Rogues from WoW, and that's his energy rather than mana. He depends on placements of special "shadows" that copy his moves and he can blink between them.
This also leaves out the fact that LoL has 5 wildly different roles that are played on a team. From what I've seen on Dota 2, I believe there's only 3: you have your hard carry, your jungler, and the rest are labelled as supports, but tend to weigh on the bursty mage types. In LoL, there are tons of characters that act like wisp, who are only good when put with other members of the team. Those are the supports, who carry the aura items, ward the field, and generally either have heals or CC.
I'm aware that Dota 2 has certain character who do this same function, but it's rare to see them in a major tournament. For example, you aren't going to see Na'Vi run an Omniknight, or even a Lich very often. Sure, Wisp is a beast of a support, but he's the only one you will see in most games.
In LoL, you can narrow down the supports that the pros play to a group of 10 or 12 champions. And you will see those champions a TON.
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