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A boss in MadWorld who returns as a playable character in Anarchy Reigns. Big Bull is a large cyborg equipped with a jetpack that moonlights as a Jet Hammer.
Brain is the disembodied brain of a German scientist. He is the partner-in-crime (and love) of Monsieur Mallah.
A boss in the Grim Adventures of Billy & Mandy.
Drakken is a evil scientist who battles Kim Possible. Like all evil scientist he has a helper, his helpers name is Shego. Drakken is a would-be-world conquerer.
Dr. Gero is a scientist that worked for the Red Ribbon Army. When Goku destroyed that organization, Gero swore revenge, and created androids to kill him.
G.O.D. is the main antagonist in Cyberbots: Fullmetal Madness.
Gordon is a disembodied alien brain that appeared in Sam & Max Episode 301: The Penal Zone.
The main character of Evil Con Carne.
Krang is a villain from Dimension X in the Teenage Mutant Ninja Turtles universe.
The final boss of Metroid and Super Metroid.
The second boss in 'Splosion Man, A scientist at Big Science Labs with a nasty addiction to anatomy altering brews. He doesn't pack much of a punch, however his bulbous brain is happy to oblige.
A mutated pile of human organs.
Natuarl Killer Cyborg is a boss in Mother 3. It is a giant robot that guards the entrance to the 100th floor of the Empire Porky Building.
No-Girl is a telepathic mutant who exists as a disembodied brain.
Robo Fly is a Psycho Fox boss, appearing in stages 2 and 4. It is, as its name implies, a robotic fly. It shields a large brain under a glass dome. Robo Fly is vulnerable to pesticide.
An NPC in the Bloodborne DLC "The Old Hunters".
Sammun-Mak was an Egyptian pharaoh that appeared in Sam & Max: The Devil's Playhouse.
The straw filled inhabitant who wished he had a brain. Later in the books, he was made a ruler of OZ. Coincidence? I think not.
The commander of Hell's forces in the wake of the Phobos incident near Mars.
Terroreyes is one of the ghosts in Ghost Master.
A street-wise, sexy and dangerous stripper who is the loving sister of crippled genius Jasper Guns. She vows to kill Papa Caesar to avenge Jasper's death.
Brilliant strategist of Shu Han. Known far and wide as the Sleeping Dragon, a man of great learning and wisdom. Instrumental in the founding of Shu and the rise of his lord, Liu Bei, Zhuge Liang is best known to people today through appearances in the Dynasty Warriors franchise.
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