Just started playing the pc version. But the game is feeling a bit chunky. I remember FO3 running a bit smoother and now I have better hardware. Phenom II x4, HD 5850, 4gb ddr3. 
 
I get 40-60 FPS just walking around the wasteland, but indoors the FPS just dies. Sometimes in town as well. I monkeyed around with the advanced settings but couldn't find any combination of AA,(off, 2, 4), Anti, any of the other random settings to get a noticeable increase if FPS. Had to drop texture quality to medium and now I can barely read the words under the screen on the pipboy. V-sync off didn't give any noticeable improvement as well.
 
Anyone got an recs to get some more frames without sacrificing texture quality? 
 
I read a few tutorials on the gamebryo engine settings and such. One website was very in depth in regards to FO3, but my results were not that great.

There are 2 different DLL files that can be downloaded out of the Nexus one is better suited for ATI the other for Nvidia cards, they seem to be working for a lot of people myself included.

" There are 2 different DLL files that can be downloaded out of the Nexus one is better suited for ATI the other for Nvidia cards, they seem to be working for a lot of people myself included. "

I'll check that file out if I can find it one there.

Yeah. I turn everything up to 1920x1080, 2X antialiasing, 8X filtering, and Ultra settings. I just installed the 3rd party directX dll and everything runs smooth as butter. on my aging 3 year old PC. I can't wait to run this again on my upcoming dream class gaming rig I'll be building next month.

yeah that dx9 dll will fix alot of the problems your describing. 

FUCKING MARVELOUS! FONV now runs like it should on my rig now. 
 
I could just tell something wasn't right, glad I asked and thanks for the help.
 
55-60FPS with settings cranked up to ultra.  8xAA too.
 
here's the page if anyone is too lazy to look   http://www.newvegasnexus.com/downloads/file.php?id=34778
 
 edit: Found some of the same mods I used in FO3 but for FONV. 
 
MTUI mod and centered 3rd person camera. I remember there being an entire reworked texture pack or something, wonder if there will be one for new vegas as the textures do look a bit blurry.