Getting this from gamefly tomorrow.  Does anyone have/know a list of bugged quests to avoid or certain things not to do without 100% spoiling them?  Would be very much appreciated. 
 
Also I heard the ending was like the original F3 ending (aka you are done done), is there an obvious place to save to explore/do side quests?  If not when should I make an extra save? 
 
Thanks y'all

Personally, I make TONS of extra saves. Basically, at the end of everyone of my play-sessions I create a new save. Knowing that the game is as buggy and unreliable as it often is, I would never risk only having one non-autosave, but that might just be me.
 
I can't give you much info on the list of bugged quests because I really don't know. One thing I do know is that I read on a Fallout wiki that for the "one for my baby" quest it says that Boone should get upgraded armor when you finish the quest and that there is a known bug that he sometimes won't get it. Well, I don't know that he really even is supposed to get this armor considering I only even heard he was from this wiki (and it never says anything like that in the game), but he never got it for me. I loaded a save several times and re-completed it and no matter how many times I tried he never got it, so I don't know.

Hey bro. I haven't played this game yet but I do no a couple of things that you want to know: 
 
1. The game creates a backup save for you right before the end that you can go back to when you beat the game. 
2. The game makes it quite clear that you are about to enter the ending, and lets you make your own backup saves etc. 
3. Yes, it is just like F3 where you can't continue from the end (and they claim there will be no DLC that will change that). That's why they did points 1 & 2. 
 
Good-luck with the glitches. I pre-ordered my copy online and still have yet to receive it. Hopefully the patch will come out when my copy arrives.

Debt Collector is a big one you should avoid. It's a side quest you get from the Atomic Wrangler. I am no longer able to get into the strip because of it. Every time I try all I get is a black screen. I've decided to stop playing until they patch the game. Apparently there is a slight fix for this by wearing an old cowboy hat but fuck that they need to patch it as there are some other quests that are bugged but not nearly as bad as this one.

" Debt Collector is a big one you should avoid. It's a side quest you get from the Atomic Wrangler. I am no longer able to get into the strip because of it. Every time I try all I get is a black screen. I've decided to stop playing until they patch the game. Apparently there is a slight fix for this by wearing an old cowboy hat but fuck that they need to patch it as there are some other quests that are bugged but not nearly as bad as this one. "