I'm at a point now where I can't seem to progress any further because of a real nasty bug.  My 360 locks up completely whenever I try to enter The Strip.  After rebooting, I can't "continue" the game either because the Auto-save is corrupt.  Luckily, I stagger saves, rotating through 4 save slots to protect myself from this sort of nonsense.   If I delete the corrupt auto-save and then load one of my manual saves I'm able to play again, but as soon as I try to enter The Strip it attempts to load and then I get a black screen and a hard lockup again.
 
Anyone have any ideas as to what I can try to get around this?  I've installed the game, so it occurred to me that I could delete it from the 360 and try playing from the DVD again but I haven't tried that yet.