If you're using Chrome, a good workaround in the meantime is to install the Stylebot extension and set the Font Weight for the fuzzy font elements to Normal. I haven't grabbed all of the elements yet, but here's a screenshot of a few of them in Style bot:
Echoing what others have said - it depends on the game. I think the most I've ever replayed due to lost progress was with Fallout New Vegas.
When Fallout New Vegas came out, I had a bug where my companion disappeared, but I could not retrieve it or hire a new companion. So I restarted it, around 6 hours into it.
About 8 hours into a new playthrough, my save was corrupted. I've never looked back.
@tathertron: I never had this issue until recently. I'm using the same version of Chrome (all extensions disabled). I do not experience the issue in Firefox 18.0.1.
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