Generally, I don't even entertain the question "Who would make a great [insert video game character here] in a movie" because it's a total waste of time.   Yesterday, however, I hadn't been playing Uncharted1 for very long before I realized that Nathan Fillion would make the perfect Nathan Drake in a movie.  Obviously, other people have seen this similarity as well if you take a look at the Nathan Fillion page on GB.   Additionally, Bruce Campbell would make a great "Sully ."