@cirdain: Each processor in your machine runs a seperate simulation and each simulation is designed on a particular type of processor. Your CPU will run in low, medium or full mode. The only way they found to run GPUs in a "medium" mode was to flick them on and off very quickly, which is neither useful nor good for your hardware. They are therefore locked at either full or off. I hope that explains it, but if not please ask any more specific questions you might have.
@ajayraz: The memory footprint is tiny, though I leave it on medium power to keep my computer usable even while it's running (You can even turn off CPU usage and just use the GPU if you go into the advanced client). The GPU only runs at full or off while the CPU contributes so little that I don't mind knocking it down a peg.
I've had my doctor girlfriend explain what exactly we are simulating twice and I still don't fully understand it. I get that it is about understanding how various proteins fold from one form into another and that this has a relationship to genetic mutations which lead to cancer, alzheimers (which both my aunt and grandmother-not-actually-in-law have) and many other bad things. She is very excited about the whole thing so I infer that it really is very useful.
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