@bladededge: I have the exact opposite feeling. The power of your character relative to opponents can vary so widely in Isaac based on what kind of drops you get that it can become a total chore to whittle down enemies' health while staying alive, and I often felt like I lost simply because I had a shitty loadout. In Nuclear Throne, your run ultimately hinges on how well you can position yourself and aim at enemies. You can beat the game with most of the starting weapons and virtually any mutation loadout if you're familiar with the enemies' behaviors. There might be a spawn in 50 that is so difficult to navigate safely that one could consider it an unreasonable difficulty spike, but generally you're left with more than enough time to carve a path to security if you calmly and quickly clear out enemies. I feel the similarities between Isaac and NT are really overstated, though. They're both permadeath proc-genned shooters, but the pace of play and design methodology are so different, it's like trying to compare The Last of Us to Ratchet and Clank because they're both third person shooters.
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