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Albino mob boss with super strength and durability.
Cindy Moon was bitten by the same radioactive spider that bit Peter Parker.
New York sees Martin Li as one of its greatest philanthropists, but this facade only hides his true identity -- crime lord Mister Negative, enemy of Spider-Man.
Spider-Man's beloved aunt, May Parker.
Miles Morales is the new Ultimate Spider-Man, after Peter Parker died in a shark-jumping battle with the Green Goblin. He has almost the same exact powers as Peter Parker, plus bioelectricity and invisibility.
Scream is a child of the Venom symbiote, forced to birth when Venom was captured by the Life Foundation. Her real name is Donna Diego.
The editor-in-chief of the Daily Bugle in Spider-Man games. Has an agenda against the wall-crawler. He is portrayed by J.K. Simmons in the Sam Raimi Spider-Man Trilogy and the Marvel Cinematic Universe.
An acclaimed novelist suffering from a serious, long-term case of writer's block, Alan Wake and his wife Alice retreat to the obscure town of Bright Falls, Washington, to escape the bustle of New York. When Alice goes missing, Alan seeks her out while battling against a mysterious dark force that threatens everything.
The Chameleon is actually one of Spider-man's earliest super-villains. A master impersonator, he uses his costumes for villainy and fun.
Kraven, the world's greatest hunter, is obsessed with killing Spider-Man, whom he views as the ultimate prey.
Dr. Curt Connors is a scientist in the Marvel Universe who transforms into the vile Lizard, usually fighting Spider-Man.
A red-headed woman who frequently acts as partner to Peter Parker's Spider-Man.
Vulture is a villain in Marvel Comic's Spider-Man Series. Adrian Toomes created the flight suit and became the Vulture.
Mysterio is a villain from Marvel Comics. He is specifically Spider-Man's enemy. He is recognized by his large fishbowl helmet and his use of illusion. He was portrayed by Jake Gyllenhaal in Spider-Man: Far From Home (2019).
Rhino is a nemesis of Spider-Man. His costume gives him superhuman durability and strength.
Electro is a primary nemesis of Spider-Man. He has the ability to generate up to one million volts of electricity.
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