Yu-Gi-Oh! Reshef of Destruction is a role-playing/card game developed by Konami Computer Entertainment Japan and published by Konami Corporation for Game Boy Advance.
The Millennium Items have been stolen! Join Yugi and friends on their journey to stop the Dark Being Reshef from shrouding the world in darkness. Players must traverse the globe finding the seven Millennium Items to release the only thing that can defeat Reshef, the three Egyptian God Cards.
In Reshef of Destruction players are put in the role of a duelist that tries to defeat Reshef with the help of the main characters from the Yu-Gi-Oh! series. Players walk around various locations, talking to NPCs and dueling.
The rules have been altered from that in the physical card game to include a rock, paper, scissors element in which lower attack monsters can instantly destroy any monster based on the card's element.