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In both Leon Kennedy's A & B scenarios, Ben will be encountered in the R.P.D station's underground prison. He has purposely locked himself up in a cell to protect himself from the zombies. Leon demanding his help and some insight into what is going on will eventually lead Ben to reveal the nearby back entrance that Leon and his current ally Ada Wong can take to safety.
Upon his inadvertent return to the underground prison, Leon will hear Ben yell in pain from his cell. From there on, depending on what scenario, Ben will be attacked. In Scenario A, William Birkin in his first G-Virus induced transformation will implant an embryo into Ben causing him to go unconscious. Scenario B will have Ben simply beaten by William. Once Leon arrives, Ben will either die from his wounds (Scenario B) or will ''give birth'' to the embryo William implanted in him, with it tearing out of his chest. That same embryo will then grow to become a boss battle soon after.
Before he dies, Ben hands Leon evidence to proving Chief of Police Brian Iron's corruption and his association with Umbrella - the decoy Pharmaceutical company that created the T-Virus.
In Claire Redfield's Scenario B story she will also encounter Ben, but only as a corpse left from the embryo bursting out of his chest back in the prison during Leon's A Scenario
Set before the events of Resident Evil 2, Ben plays a small supporting role in the level ''Desperate Times'', once again found locked up in the same cell. The player character has to find him the same evidence that Ben will eventually hand Leon, insinuating Brian Iron's involvement with Umbrella and the bribes he has accepted over his career.
For some extra ammunition and items, the player can locate films throughout the station and exchange them with Ben.
Upon completion of the level, the player may then purchase Ben's character skin, set over the character David King's model.