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A robot master from Mega Man 4. His weapon is the Skull Barrier.
One of Magus' generals during the Middle Ages.
A colossal Brute and leader of the bandits in the Arid Badlands.
The last boss in Burai Fighter. This green-scaled slimeball is the master of the Burai, and easily your most fearsome adversary. He will shoot molten rock curve balls which are indestructible. Keep on your toes, or you'll end up as dragon bait!
Smash Daisaku is second in command of Empire Army. He is a recurring villain in Gunstar Heroes, and boss of the game's fifth stage.
Smithy is the main antagonist of Super Mario RPG. Smithy's ultimate goal is to conquer the Mushroom Kingdom. Why exactly he desires this is not known.
A boss character from Diddy Kong Racing.
Sniper Wolf is a deadly sharpshooting boss from the first entry in the Metal Gear Solid series. She is voiced by Tasia Valenza and Naoko Nakamura.
Boss in Mega Man Zero 4. resembles a moth.
Solid Arm is a recurring villain within the Soul Blazer series who first appeared in Soul Blazer, and made an appearance as an optional side boss in its sequel Illusion of Gaia.
A character from the "Lightning Warrior Raidy" series of pornographic RPGs.
The #3 ranked assassin in No More Heroes. She's an old lady with a shopping cart that transforms into a gigantic laser cannon.
A bounty hunter from Metroid Prime Hunters. The last of his kind, Spire seeks the Ultimate Power to discover the mystery of his vanished race. His Dialanche Alt-Form has the unique ability to scale walls.
A boss in the Silent Hill franchise.
A boss in the Ratchet & Clank:all 4 one game
Spoiled Rotten is an eggplant like Wario boss. She has two plant warriors to help and a doll.
Squizzard is the boss character faced in the Slipsand Galaxy in Super Mario Galaxy 2.
The king of reincarnated skeletons. He's pretty huge.
Mid-Level 1 boss in the game Toki:Going Ape Spit. Also called Moornar in the NES version.
He's the first mini boss in the Super Nintendo RPG "Earthbound", and later appears as a normal enemy.
Steven is the Hoenn Pokémon Champion. He specializes in Steel-type Pokémon.
A psychopath from the original Dead Rising and Dead Rising: Chop 'Till you Drop. He doesn't allow vandalism in his store.
Straga is the last and greatest of all The Destroyer's Chosen in Darksiders, and the embodiment of his dark tower.
A Dark Souls boss encountered upon revisiting the game's opening area, the Northern Undead Asylum. The Stray Demon returns as a mini boss in Dark Souls III found in Farron Keep, above the Old Wolf of Farron bonfire. It is unknown if it is the same demon.
A rouge Strider from Strider 2 that appeared as a boss. He wields a ranged Cypher that returns to him when thrown.
Some might call him an evil alien robot with a kickass CO power, but others just call him Sturm. He is the main villain of the first two Advance Wars games.
One of the bosses in DmC who is a 1,200 year old demon whose toxins she secretes and vomits are used as the "secret ingredient" of the drink Virility.
Sulfuron Harbinger is the seventh boss in Molten Core.
A dangerous cyborg mercenary and member of the "Winds of Destruction". Despite not officially running Desperado Enforcement LLC, he's generally believed to be pulling the strings of the PMC.
One of the most popular hunters from Metroid Prime Hunters. A sworn enemy to the Galactic Federation and Samus Aran, Sylux seaks the Ultimate Power for reasons unknown, though obviously dubious. His Shock Coil Affinity Weapon sucks the life out of his opponents.
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