Isn't the game real short, I think a game needs to be 30+ hours to be considered endurance material.
Dragon Age II now that would be an endurance run.
DMC is perhaps like 5-6 hours long on average, though given how much trouble Brad had with Nelo Angelo, it would no doubt take him a fair while to complete it. I'd envision him getting stuck at the third Nelo Angelo fight, as he's easily the toughest boss in the game.
Plus we don't know if Brad's planning on playing through the entirety of DMC. Next episode he may well just move onto DMC2 or DMC3 -- though hopefully he'll just skip DMC2 altogether.
I'd like to see him play each game until he gets officially sick of them, I guess. I'd actually like to see him play DMC2 for the potential hilarity that may ensue.