Hey guys I'm about to start this game, and I have a quick question.  Are there difficulty-related trophies in this game?  I want to go for the platinum, but I don't want to look at a full trophy list in fear of spoilers.  I know some (or all) are hidden, but I'm patching the game right now so I can't check for myself.  Thanks in advance.

I'd suggest playing the game on the hardest difficulty anyway, It's really not difficult ;)  
Plus you'll have to play through the game multiple times to get the platinum trophy. 

Once you complete a chapter, you'll be able to replay it at will. So just finish the game once and replay whatever chapters you need to in order to get your trophies. That's how I did it  ;)