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Giganta is one of the most powerful DC villains. She has given trouble to Wonder Woman from time to time.
Harleen Francis Quinzel is a former doctor at Arkham Asylum, and the Joker's accomplice and lover in the Batman universe. She is known for her Jester-like aesthetics, childish behaviour, and psychotic devotion to the Joker. She is best friends with Poison Ivy.
Killer Frost traditionally appeared as an enemy to Firestorm in the old comics.
Lex Luthor, beloved billionaire of Metropolis, is also the arch-nemesis of Superman. Lex Luthor despises Superman because until Superman came around, Luthor was the most powerful man in Metropolis. Now Luthor has dedicated his life to eradicating the Man of Steel.
A cyborg fitted with a heart of kryptonite, Metallo is one of Superman's most feared enemies.
Obsessed with plants, Poison Ivy uses them to her advantage to stop heroes like Batman. She is immune to all poisons and chemicals. She is Harley Quinn's best friend and sister-figure.
Sinestro was once considered the greatest Green Lantern, but his oppressive police rule of his home planet and his increasing aggressiveness forced the Guardians to ban him. Now he's their greatest foe and leader of his own Sinestro Corps.
Carol Ferris is the oft-love interest, sometime enemy, and sometime ally, of Hal Jordan the Green Lantern.
Enemy of Superman and villain in DC Universe Online.
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