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Spider-Man villain.
Though created by Odin in the Marvel Universe, this mystical armor designed to protect Asgard often falls under the wrong influence.
A friend and coworker of Peter Parker's at the Daily Bugle.
Kron Stone is an enemy (and former classmate) of Spider-Man 2099, whose DNA was crossed with that of a scorpion in a lab experiment gone awry. He has also been host to the Venom symbiote.
Rhino is a nemesis of Spider-Man. His costume gives him superhuman durability and strength.
In the Marvel Universe, a mythological hulking beast that roams the Canadian wilderness, attacking and ingesting those unlucky enough to cross its path.
Russian enemy of Iron Man who wears a similar super-powered suit.
Enemy of Iron Man.
Just A Rather Very Intelligent System or J.A.R.V.I.S. is Tony Stark's artificial intelligence.
Ultimo is from the Marvel Comics universe. He was once under the control of Mandarin and being used to fight Iron Man, but he even occasionally fights Iron Man of his own will.
Billy "The Beaut" Rosso is one of the Punisher's biggest enemies. He became Jigsaw after The Punisher disfigured his face.
Spiral is a henchman for Mojo. She has teleportation powers, and six arms.
Former sidekick of Moon Knight in the Marvel Universe, who now wants to kill him.
Acolyte to Magneto in the Marvel Universe.
Cloak, along with Dagger, is a runaway. They are two lonely teenagers who ran away to New York City to seek a better life. Fate, however, had other plans for them.
Traditional sidekick of many Marvel superheroes. For a time he was a super-powered Hulk-like creature known as A-Bomb.
Songbird is a super-heroine and former villain in the Marvel universe. She leads a team of reformed villains known as the Thunderbolts.
Leader of the Mutant Response Division in X-Men Destiny. He was created just for the game.
God of evil in the Marvel Universe with incredible power.
Often associated with Doctor Strange in the Marvel Universe, Nightmare is the ruler of the dream dimension and a co-creator of the Fear Lords.
Electricity-based enemy of the Hulk and other Marvel Universe characters.
Tiffany is the American transfer-student from Pacific High. She utilizes her kickboxing and cheerleading skill when fighting, and has the largest bust of all the Rival Schools females.
Miles Morales is the new Ultimate Spider-Man, after Peter Parker died in a shark-jumping battle with the Green Goblin. He has almost the same exact powers as Peter Parker, plus bioelectricity and invisibility.
Spider-Man villain who transferred his own brain waves to a robotic double. Expert in robotics and chemistry.
Stan Lee is the creator of many of the most famous characters in the realm of comic book characters. He is a character in a few video games as well.
Alternate reality Spider-Man set in the 1940s. He was voiced by Nicholas Cage in Spider-Man: Into the Spider-Verse (2018).
Mummy from the Darkstalkers series of fighting games from Capcom. Although he is slow, he has a wide range of unique moves.
The wife of a deceased high-ranking mafia hitter turned ally of the Punisher.
Protagonist of the game God Hand. Gene is the wielder of the God Hand, a weapon of God-like power. Before he is in control of the God Hand he is a drifter until he gambles with a bad gang and in exchange for money they cut his arm off.
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