Official Xbox Editor Jon Hicks has told CVG that the mag will next month reveal the return of a "substantial franchise" - as an Xbox exclusive. 
http://www.computerandvideogames.com/article.php?id=242499

Duder!  Could it....could it be Shenmue III? Most likely just getting my hopes up once again but that would be freaking amazing and one of the biggest shock announcements I'll have ever heard in the gaming industry.
 
As I say though, it's incredibly unlikely but after some intense Google research (more like 10 seconds worth) I came across this nugget of information which has fueled my hope for this to be Shenmue III some more;
  

Sega recently told Famitsu magazine that Shenmue 3 is still talked about as a possibility at the company. The problem is poor sales compared to the costs of making the game. Sega assures fans that were there ever an opportunity to revisit the franchise then it could happen.   
http://gamer.blorge.com/2010/01/30/sega-hasnt-given-up-on-shenmue-3/ 

Further reasoning for my belief that this could be Shenmue III is that Shenmue is hailed as a classic, innovative and way ahead of its time. I think it's earned the right to be called a substantial franchise as it has one heck of a legacy. Shenmue II was also released on the original Xbox (exclusively)with English voiceover work, the Dreamcast version had Japanese voicework only.
 
Still, I am like I say most likely getting my hopes up for nothing.