@amatureidiot: I know this thread is old, but have you found anyway to keep the game feeling fresh? I recently got it from a sale and played it a lot for the past few days, but am feeling burnt out already after realizing there's not much to gain (if anything) from beating the boss again. What you pointed out is exactly how i feel, binding of isaac kinda spoiled me given that not only are you unlocking new characters but a hundred or so items of the course of beating it over and over.
Use your keyboard!
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