EDIT: sorry, i should be clearer, this is based on the Game informer article lol.
 
1) The idea of having it in a city (which looks very cool) with elementary schools, office buildings, shopping centers, and churches. 
 
2) Making Isaac more prepared, but not making him some super Leon Kennedy guy. 
 
3) Making the controls more reliable and open, so the game depends on your skill more than restrictions of control. 
 
4) Peng is back in billboard form. 
 
5) They are trying much harder to make the game scary. 
 
6) They want us to be scared. 
 
7) *cough* multiplayer *cough* (What? the more I can get, the more fun I'd have. Also if it's dumb, then I won't play it... which... you know... is what everyone should do) 
 
8) Knee Jet Booster 
 
9) The idea of not making this a haunted house, but rather a strategy game in which you and the enemy are kind of playing it cat and mouse game (It's not a strategy game, literally, don't worry... they'd be pulling a Tim Schaffer BUR-) 
 
10) A Javelin Gun 
 
11) Much more back story (but I kinda don't like the idea of Isaac talking... lets hope he sounds good) 
 
12) The weapons will be more useful, even if it's for specific enemies (I'm looking at you, flamethrower) 
 
13) Gaining more control when shooting through areas in Zero-G 
 
14) Children Necromorphs (k now it's like Space Silent Hill XD) 
 
15) More focus on the combat, which was already pretty good in Dead Space, so I'm excited to see how this turns out. 
 
This game is now totally my most anticipated game of 2010, right next to Heavy Rain and Dead Rising 2