Well here's my list for games that I consider must haves,
 
 PS3
 
 5. White Knight Chronicles: I love my RPGs, but this one looks to generic to get any higher
 
 4. Heavy Rain: This reminds me of Indigo Prophecy, a game i loved
 
 3. Uncharted 2. A action game with a sarcastic hero? sign me up
 
 2. Atelier Rorona. The Atelier Iris series has always given me hours of fun an i expect this to be no different (since the three iris games where basically the same game as far as mechanics go)
 
1. Ratchet and Clank Futures: A Crack in Time, Probably one of the funniest franchise of this generation. Each R&C game gives me a new reason the the franchise while reinforcing the previous reasons
 
360
 
 2. Alen Wake This looks like a fun and innovative survival horror game, so what if one of the innovations looks to be the removal of horror  
 
1.Mass Effect 2. This shooter with RPG elements looks to be a vast improvement over the first while still maintaining what it it so fun, though hopefully you can have a more cynical character.
 
Multi-platform  
no order here 
  
Assassins Creed 2
Bayonetta 
 Battlefield Bad Comapny 2
Dante's Inferno
  Final Fantasy XIII 
 Dead Rising 2
Jak and Daxter: The Lost Frontiers.
 
Wii   
 
1. No More Heros 2

DS
  
1. Atelier Annie, for pretty much the same reason as Atelier Rorona