So, I just got the armor upgrade in Prototype and the first thing I thought was "It's the Guyver!". Observe:

Gallery

I see where you're going, though I don't necessarily think that was what they were doing.  Maybe, though.

More importantly, that first screenshot looks like this big buff bio-armored man-beast is wearing a little white skirt. Yes. That is of importance.

Reminds me more of the Nightshade armor I used to use in Oblivion.

http://www.tesnexus.com/downloads/images/14999-4-1201621320.jpg

<3 the live action guyver movies sooo much.

Hahah holy crap I never even though of that. It is Guyver!

but can the prototype guy do the mega buster?

haha this is actually the first thing i thought of when i first saw the armour. Not seen Guyver in years but there is no denying it looks very similar.

The first thing I thought about when I saw that armour is actually this Tsutomu Nihei manga:

http://www.onemanga.com/Abara/

A one specific character in it had pretty much the exact same power which looked somewhat similar.
On a totally unrelated note. How freaking weird is that Guyver's ultimate(?) power is flashing you with his yellow bio boobs. Ah Japan. :)

*remembers guyver the anime and the live action.* childhood memories...

Yeah, I was wondering why it looked so familiar.

I was thinking more along the lines of a Berserker from Gears of War.