So I heard the Apoco-Fist can only be gotten by making a certain choice at the end of a specific mission. I guess the same goes for whatever item you get for making the alternate decision in that mission as well.

Are there any cool or awesome items that you can totally miss out on like this that I should be aware of in my playthrough?

Don't think so, there are some cool DLC weapons though. You don't get a separate item for giving up the apocofist, just a cosmetic change to cutscenes.

Oh? I thought you got Killbane's Mask which can light people on fire when you taunt them?

Good to know there aren't other things where your choices can cut out really cool items/weapons. I'm fine with choosing one or the other most of the time, but this just seems like two awesome things to have to give one up.

That mask indeed lights people on fire when you taunt them. I have it. It was also worth it for the catharsis of removing it. Still a painful choice to make between that and the apoco-fist. My spiteful personality won out in the end though and I got the mask.

Goddammit, I gave up the awesome fucking Apoco fists for story purposes... Now I really wish I could get them. 
It seems so weird to have the one singular gameplay affecting choice.... Shit, they let you replay the entire ending again to get everything.
 
@yevinorion: Your spoiler tags are correct, that is what you get.

Fart in a jar is all you need...

During the mission where you sign off on two out of three S.T.A.G. projects (the hover bike, the satchel charges, or the enhanced tank), you are given the two you sign off on and can't get the third elsewhere.

@Geo7877 said:

During the mission where you sign off on two out of three S.T.A.G. projects (the hover bike, the satchel charges, or the enhanced tank), you are given the two you sign off on and can't get the third elsewhere.

Which two are generally considered to be more worth choosing?

@Trav: Choose the hoverbike. Your second choice can be whatever but choose the hoverbike for one of them. I went with the tank but now I'm thinking of fun things I could do with satchel charges.

@Trav said:

@Geo7877 said:

During the mission where you sign off on two out of three S.T.A.G. projects (the hover bike, the satchel charges, or the enhanced tank), you are given the two you sign off on and can't get the third elsewhere.

Which two are generally considered to be more worth choosing?

The hover bike is a definite choice.

Between the other two really comes down to how you want to play. Would you rather set charges and remotely blow things up, or would you rather have a heavily armored and more powerful tank to go rampage with?

I went with the bike and the tank, because I doubt I would ever use the charges (and they replace the rocket launcher slot).

Yeah hover bike sounds like a must-have. I'd probably go tank as I do enjoy satchel charge style explosives, but a super tank is pretty hard to argue with.

I wonder if there may not be some way to get both the Fist and the Mask? I saw some guy on the official forum saying you can download a character/outfit from the site that already has the mask on and get it that way, but he had no replies to his thread so I don't know how valid that is.

@yevinorion said:

Yeah hover bike sounds like a must-have. I'd probably go tank as I do enjoy satchel charge style explosives, but a super tank is pretty hard to argue with.

I wonder if there may not be some way to get both the Fist and the Mask? I saw some guy on the official forum saying you can download a character/outfit from the site that already has the mask on and get it that way, but he had no replies to his thread so I don't know how valid that is.

I have heard that that worked as well, and will probably try it out once I get to the end of the game.

Thanks guys. And is there any kind of NG+ after you beat the campaign the first time?

@Trav said:

Thanks guys. And is there any kind of NG+ after you beat the campaign the first time?

Nope, nothing of the sort. You can replay the final mission of the game, but that's all.