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Diablo is the Lord of Terror and the most powerful of the three Prime Evils of the Diablo Universe.
Dimentio is a magical jester and antagonist in Super Paper Mario. He manipulates both the game's heroes and villains to achieve his own ends.
Dimitri Rascalov is a Russian criminal in Grand Theft Auto 4. He is the main antagonist in the game.
Doctor Doom is a supervillain from the Marvel Universe who is bent on world domination. He is the ruler of Latveria and the primary antagonist of the Fantastic Four.
Is the main villain in the crash bandicoot games. And a mad scientist who's plan is always thwarted by Crash, who he created. He is thought to be a bit crazy.
The villain of Arkanoid
A Cabal Centurion in the Destiny series and the main antagonist of the original campaign in Destiny 2. He leads an elite Cabal faction known as the "Red Legion" and aims to steal the Traveler's Light for himself.
Known as the Plobfather, Don Clawleone is the leader of the Plob.
Maxwell's opposite in the Scribblenauts series, who often serves in an antagonistic role.
Doviculus is the main antagonist in Brütal Legend and is the leader of the Tainted Coil. He was originally supposed to be voiced by Ronnie James Dio but is now being voiced by Tim Curry.
Enemy of Swamp Thing. Final boss of the Swamp Thing video game.
He is the main antagonist of the game. The president of Burnital Industries (as well as Dr. Muto's nemesis,) Burnital is the final boss of Mazon.
DePlayne, boss, DePlayne!
Dr. Erode is a huge green monster and acts as the final boss in Power Stone 2.
Dr. Jonathan Jacobo is the main antagonist of Scooby-Doo 2: Monsters Unleashed.
The Main Antagonist of The Ratchet and Clank series and is the most recurring villain. He hates all organic life and is pro-robotocism alone despite formerly being one. He is the Archenemy of Ratchet,Clank,and Captain Copernicus Qwark.
Character in the Mega Man Battle Network franchise. He is the leader of Nebula and the main antagonist of Mega Man Battle Network 4 and 5.
Dr. Robotnik, also known as Dr. Eggman, is the antagonist in nearly every Sonic the Hedgehog title.
Dr. Venom is a recurring antagonist in the Nemesis, Gradius, and Salamander series. He developed the Vic Viper and Metalion, but turned rogue when the Gradius government turned a blind eye to the plights of his people.
Main Antagonist of Mega Man Zero 4. he is the former ruler of Neo Arcadia.
Dr. Wily is the insidious inventor of the various Robot Masters that plague the year 20XX. His jealousy and hatred for both Mega Man and Dr. Light has compelled him to mastermind various plots to do away with them throughout several games.
The DracoLord is the arch enemy of the first Dragon Quest game. His grandson also appears in Dragon Quest II, and aids the party. In earlier versions of the game, he was called the Dragonlord.
Dracula is the antagonist of Bram Stoker's 1897 Gothic horror novel Dracula. He has been featured in many video games, primarily in Castlevania.
Drawcia is the main antagonist of Kirby: Canvas Curse.
The main antagonist of Warhammer: Dark Omen, commanding armies of the Undead
A fusion of Lavos and Schala, the Dream Devourer is the final boss in the DS-exclusive ending to Chrono Trigger.
Once a hero during the Great War, Duke saw the horrors of mankind and ended up losing faith in humanity. Because of that he is an ominous recurring figure in Tales of Vesperia who both helps and hinders the characters of the game.
The final boss of Super Double Dragon and Koga Shuko's second-in-command in the Neo Geo title.
Duo is the final boss of Mega Man Battle Network 4. He is the OS of an artificial asteroid set to collide with Earth.
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