Your friend and mine, @marino hasn't put up a 2017 version yet but each year he's tweaked and updated a PAX guide on a rolling basis going on 6 years. As someone getting up there in my own PAX experience (this will be 10th or 11th at this point), I can vouch for practically everything in that guide.
For me personally, I like to make my own schedule for panels with all the details so I know who to see when and where. Take a look at the schedule on the website and download the PAX East app if you can and look at the maps for the convention and the exhibition hall.
The conventional wisdom is that, depending on how popular the panel is, the time to line up ahead of a panel is from about 30 min to an hour. The Giant Bomb panel tends to be an exception since it brings in so many people so if you want to be somewhere reasonably close, then lining at least an hour early is a good start. Keep in mind that you can't line up for any panel until the panel before it starts; this year, the earliest you can technically line up is about 7:30 pm. Some people sweat lining up for the panel but in all my years of going to the GB panel, I've never seen people unable to get in.