Seriously,  
 
Imagine this game, a first person rpg in the theme of The Elder Scrolls or Fallout 3 where you have a huge, open world city but with a cyberpunk setting.  There would be a main quest line that (like Oblivion or Fallout 3) is optional to see to the end.  Include different factions (Corporations, various gangs) that you can align yourself with for side quests and a whole bunch of other stuff to do if you want.  Allow the player to truly create their own character that can be a hacker, a melee fighter (stealth), a shooter, or a mix of the three.  Also allow a wide variety of cybernetic augmentations that could either be quest rewards or the result of a corporate raid that you can undertake. 
 
 So, basically, a Cyberpunk Oblivion.  That is the game I've been secretly hoping for for a long time now.   And unlike  Deux Ex: HR, I want a game that is RPG first and action second (like an Elder Scrolls game).  And for a really awesome bonus, make the whole thing a Shadowrun game.  (Yeah I know that will never happen, but if I'm wishing for something I might as well wish big)
 
 
Hell, this game idea practically writes itself.  
 
So, game industry... DO IT.