If you want to put games or other programs like photoshop or sony vegas on a RAMDisk you can do that. RAMDisk basically makes your RAM into a SSD I use the RADEON RAMDisk and it is pretty sweet for storing smaller (10gb) games and the cache from web browsers. It helps with load times and cuts the information transfer time down big time since it doesn't have to pull the info off the HDD/SSD through the motherboard chipset so access times are practically 0 seconds.
Other than that media encoding is the only thing that will use that much RAM like crusader8463 says.
here is the link for a free trial if you want: http://www.amd.com/us/products/desktop/radeon-memory/Pages/ramdisk-promotions.aspx any RAM will work you don't need to have anything AMD on your PC.
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