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Santa Destroy is the main setting for the two games in the No More Heroes series. Aesthetically designed to be a parody of American cities such as Los Angeles, it is home to Travis Touchdown and his various missions, assassinations or otherwise. Travis personally traverses around town via motorcycle, although the landscape itself is largely lifeless, containing only sparse numbers of civilians who mill about. It does, however, sport several landmarks, most of which are either used as battlegrounds for Travis' fights or as locations where he can get upgrades and similar such things.

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