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Dural is a character in the Virtua Fighter series.
Dust of Osiris is one of the final bosses from Melty Bloody Actress Again.
Earthworm Kim is Earthworm Jim's repressed feminine side, who functions as the final boss in Earthworm Jim 3D. She also is unlockable as a playable character.
The main antagonist of Digimon Story: Cyber Sleuth.
Eddie Brock is a character in the Marvel Universe best known as Venom. He became Venom when he joined with an alien symbiote life form and was one of the most fearsome enemies of Spider-Man. He has also use the Anti-Venom and Toxin symbiotes at different points in his life.
The male Leader of the Fourth Empire.
Elpizo is an exiled reploid from the Mega Man Zero series, he joins the resistance to gain the vast powers of the Dark Elf.
Just as Nightmare/Inferno is the living incarnation of the power of Soul Edge, the cursed sword, Elysium is the living incarnation of the power of the spirit blade Soul Calibur.
Emperor Bulblax is the final boss in Pikmin. He has a lesser role in Pikmin 2 as a cave boss.
The former emperor of the Cabal Empire and later the main antagonist of the "Lightfall" campaign in Destiny 2. After attempting to recruit the Guardians from his mighty space vessel, the Leviathan, he later became a Disciple of the Witness and commander of the Shadow Legion.
The leader of Imperial Sandora. Emperor Doel seeks to conquer all of Serdio and rule the land as a tyrant unlike his late brother, King Carlo.
Darth Sidious is a character in George Lucas's Star Wars saga. Toward the end of his lifespan he reigned as the Emperor of the Galactic Empire. As a running politician he went by name of Sheev Palpatine, he is survived by a granddaughter called Rey.
Emperor Tachyon is the last known Cragmite in the galaxy, determined to gain revenge on all Lombaxes for the disappearance of his kind.
The antagonist of the Superman arcade game.
The manifestation of the negative energies, wishes, and desires of humankind. It is the final boss in the expansion of Persona 3 FES, The Answer.
Evil Jim is the antagonist of Earthworm Jim: Menace 2 the Galaxy. He originated in the Earthworm Jim animated series.
The terrible Exdeath, who seeks to destroy the Crystals in Final Fantasy V. He brings terror upon not one, but TWO different worlds. In Final Fantasy XII he appears as the esper Exodus, which is another translation of his name.
A cyborg demon; the titular antagonist of Ultima III: Exodus, and a major player in several other stories.
The final boss of War Gods.
The final boss of Mobile Suit Gundam Extreme VS. The Extreme is a pilot less mobile suit with built in A.I. It is capable of storing various armor packs capable of increasing it's form and power.
Eyedol is the final Boss in the first Killer Instinct game.
The Fairy Godmother is an antagonist of the Shrek franchise and has a prejudice towards ogres.
Fernandeath is the HUGE boss of Waku Waku 7. He is a parody of the SNK "cheap boss." Has a couple of cute wings.
The ruler of the Fire Nation, he continues the war his grandfather started over a century ago on the world.
Your "best friend".
The Dark One himself, buried in Flucifer's Necropolis.
A recurring name and face in video games by Hidetaka "Swery" Suehiro. He is a man who fills seemingly(?) unrelated roles in each story that he appears.
The main antagonist of Grand Theft Auto: San Andreas, Officer Tenpenny is a corrupt cop who heads up the LSPD's anti-gang unit, known as C.R.A.S.H.. Despite his quiet loathing of Carl Johnson, he'll always find an excuse to keep him alive.
A game developer from the AVGN series.
Known by many as a famous composer and pianist, he plays the fictional main protagonist and story teller of Eternal Sonata.
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