I just started playing Dead Space last week and went through the first few chapters before I realized that I could break the boxes with the flashing green lights to get items. I noticed them at the beginning of the game and tried to interact with one but no context came up and at the time I didn't have kinesis. Until that point I was watching my supplies like a hawk like I was playing the original Resident Evil.
So the question is have you ever done something like this? Have you ever gone through a significant chunk of a game without realizing you were unintentionally gimping yourself?
Two more examples that come to mind as I write this:
The Getaway for PS2. Went through at least half of the game without realizing you could lean on walls to regenerate health. It made the game trivial after I learned that since I became so cautious and of course had spent so much time dying that having an extra health bar or two per level felt like a cheat.
TMNT 2: The Arcade Game for the NES. I used to play that game with my cousin all the time without ever knowing you could do a power move by hitting both A and B at once. Lots of jump kicking needed to get through that game without that little nugget of info.