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This concept occurs in many RPGs and Sci-Fi games. The Ancient Advanced Civilization Technology is often a giant weapon (Halo Rings, Giant of Babil, etc.) that becomes a major plot focus in the stories of these games.
A hostile artificial intelligence, or "rogue AI", is a synthetic being that has turned on its creators. Among the most famous rogue AIs from video games are SHODAN (System Shock) and GLaDOS (Portal).
They created the Catalyst. Their form were the basis for the Reapers.
Games that feature an antagonist--someone who opposes the game's protagonist--that is a man.
The ability to influence and control the thoughts of others.
The Protheans were once believed to be a single race that spanned the known galaxy with a mighty empire. But it has been revealed that in fact 'Protheans' were a mix of all known alien species unified under one name and empire. 'They' were wiped out by the reapers.
An aphid-like species from beyond the Omega-4 Mass Relay, not much is known about these mysterious creatures. Apart from their advanced technology, the Collectors are an enigma.
In the Mass Effect franchise, the Reapers are a hyper-advanced machine race that appear periodically every 50,000 years to bring a close to a "cycle" in which the Reapers harvest all the advanced forms of life.
A malevolent character whose goals are evil in nature. While villains are commonly featured as antagonists, not all antagonists are necessarily villains.
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