As a huge fan of that movie I think that a psychological mystery/dark thriller game would be very interesting. I remember how much I loved the pervious game in the Blade Runner universe, from the now defunct Westwood Studios, and playing it numerous time to see the all of the 13 different endings. The major problem with that game was that you never fully immerse your self in the game world as the game was basically moving your character from one scenery to the next and some of the NPC's were not fully developed and just ended up being  2 dimensional, those of you who played the game will understand. 

With the great progress video games made since the this game came out in 1997 I think its about time we have another great game that explores the dark, rainy and polluted world of Los Angeles 2019. Ideas for the games can range from investigation the fate of Deckard and Rachel, how the tyrell corporation handled the death of its enigmatic leader and the repercussions of his death, hunting down the mysterious "missing" sixth replicant that is alluded to by Captain Bryant in the movie and much much more. 

I would love to hear your input on this matter and if you feel the same as I do.