The Rumble Pack, a group of obvious friends whose personalities work well together and frequently go on funny tangents.
Player One Podcast, ex-EGM, Nintendo Power, and other videogame vets
Watch Out For Fireballs, As someone who isn't going out any buying new releases that often, I echo ArtisanBreads' statement about liking in-depth talk about old games. This and Retronauts fill that role.
And No More Whoppers, Ray Barnholt's non-video game podcast where they talk about video games pretty often.