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The Sanguine Rose is daedric staff associated with the Daedric lord Sanguine, who bestows the staff upon champions who do his deeds. The Sanguine Rose has three incarnations in video games: The Elder Scrolls II: Daggerfall, The Elder Scrolls IV: Oblivion and The Elder Scrolls V: Skyrim. In Daggerfall you receive the staff from Sanguine after completing a quest to kill a priest, and in Oblivion you receive the staff after completing Sanguine's Daedric quest, which involves casting a nudity spell on a castle party. In Skyrim, you receive the staff after a drunken night where you cannot remember any of your mischievous deeds and spend the following day repairing the "damage" you have caused. Sanguine communicates with you directly and hands you the staff in his Daedric realm after you follow him there.

The staff is usually depicted by a red rose atop a wooden, gnarled branch, usually with thorns. It can be used to summon Daedra to fight for the bearer, such as clannfear or Xivilai, although the effect wears off after a few moments. In The Elder Scrolls II: Daggerfall, the rose's power fades with each use, as it is a usable item, represented by the petals on the staff slowly falling off; in The Elder Scrolls IV: Oblivion and Skyrim, the Sanguine Rose's power can be replenished, as it is listed as a staff.

During the course of Oblivion, if you gift the staff to Martin Septim during the Blood of the Daedra quest, he will reveal he once possessed the rose once.

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