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Rhino is a nemesis of Spider-Man. His costume gives him superhuman durability and strength.
Spider-Man villain often associated with Spider-Slayers, along with his father, Spencer Smythe.
Black Cat is a sometimes burglar, sometimes hero, friend and former lover of Spider-Man. She gains her abilities from a combination of magic and science.
Cloak, along with Dagger, is a runaway. They are two lonely teenagers who ran away to New York City to seek a better life. Fate, however, had other plans for them.
Tandy Bowen is a light-wielding mutant who is part of the crime-fighting duo "Cloak & Dagger"
The Chameleon is actually one of Spider-man's earliest super-villains. A master impersonator, he uses his costumes for villainy and fun.
The Kingpin, aka Wilson Fisk, is the biggest crime lord in New York City, and possibly the world. He operates under the guise of a legitimate businessman and philanthropist, much to the chagrin of Spider-Man, Daredevil, and the Punisher.
Scorpion is a nemesis of Spider-Man. He was once private investigator Mac Gargan, until J. Jonah Jameson hired him to be the subject of an experiment that gave him immense strength, a costume with a tail that fires lasers, and the deep-down crazies. He was the third Venom.
Doctor Otto Octavius was a scientist who turned to a life of crime, using a set of four flexible mechanical arms originally designed to assist in scientific research and labwork to give himself a major advantage over the police.
After being bitten by a radioactive spider during a science exhibit unrelated to school, timid teenager Peter Parker becomes the Amazing Spider-Man. Armed with the ability to climb walls and enhanced strength, Spider-Man uses his powers to fight evil and protect the innocent.
Mysterio is a villain from Marvel Comics. He is specifically Spider-Man's enemy. He is recognized by his large fishbowl helmet and his use of illusion. He was portrayed by Jake Gyllenhaal in Spider-Man: Far From Home (2019).
With a terrible track record, a costume resembling a soiled mattress, and a name that inspires fear for all the wrong reasons, the Shocker is primarily a laughingstock. This Spider-Man villain has gauntlets that allow him to generate powerful shockwaves.
Miguel O'Hara was injected with an addictive drug that would kill him if he didn't work for the company supplying that drug. He tried to cure his addiction by purifying his system on a molecular level but was sabotaged and accidently given spider-like abilities.
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