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Dr. Sivana is archnemesis of Marvel Family
Dracula is the antagonist of Bram Stoker's 1897 Gothic horror novel Dracula. He has been featured in many video games, primarily in Castlevania.
Once a hero during the Great War, Duke saw the horrors of mankind and ended up losing faith in humanity. Because of that he is an ominous recurring figure in Tales of Vesperia who both helps and hinders the characters of the game.
The leader of the gang that John Marston, Bill Williamson, and Javier Escuella were in.
Eddie Brock is a character in the Marvel Universe best known as Venom. He became Venom when he joined with an alien symbiote life form and was one of the most fearsome enemies of Spider-Man. He has also use the Anti-Venom and Toxin symbiotes at different points in his life.
Crown Princess to the throne of the Adrestian Empire, and house leader of the Black Eagles at Garreg Mach Monastery
Pucci is the main antagonist of JoJo's Bizarre Adventure part 6. He is an insane priest who worships Dio and seeks to remake the world to fit Dio's vision.
Eustace Bagge is a hard-working farmer living in the Middle of Nowhere. He has a dislike to his wife Muriel's Dog Courage, on account that he gets more attention than Eustace.
The former Hunter of Green Lanterns and Sinestro Corps Soldier, Fatality has been converted by the Star Sapphire Corps
An antagonist in Bloodborne and the game's first mandatory boss fight.
The mad doctor with a bag on his head and an oversized scalpel from the Guilty Gear fighting franchise. His crazy moves and personality makes him an oddball even in the bizarre Guilty Gear cast.
Once a benevolent and highly respected Imperial Physician, Festus has since become a champion of Nurgle, spreading diseases far and wide instead of curing them.
In the alternate timeline of Flashpoint, Bruce Wayne was murdered by Joe Chill in the alley instead of his parents. Despairing, both of Bruce's parents changed for the worse, with Thomas becoming his timeline's darker, more violent Batman.
The Sandman, also known as Flint Marko or William Baker, is a Marvel Comics character and a regular enemy of Spider-Man. He has occasionally been a superhero, and even briefly was a reserve member of the Avengers.
Your "best friend".
Officially he is "Frankenstein's monster", as the book was named after his creator, Victor Frankenstein, not the monster made of reanimated pieces of dead bodies. Nonetheless, the name stuck with the populace, and "Frankenstein" has been lumbering through horror movies and games alike for decades.
The child protagonist of Undertale.
Garon is an antagonist in Fire Emblem Fates. A cruel king who reigns over the Kingdom of Nohr, he desires to conquer and subjugate the rival kingdom of Hoshido.
The first Hunter, Gehrman resides within the Hunter's Dream and provides occasional bits of advice to the player.
General Grievous was an antagonist from Star Wars Episode III, and features heavily in all Clone-Wars related Star Wars projects, including videogames. He is a cyborg general for the Separatist army who possesses four arms and the ability to wield Lightsabers.
Known as the Conqueror of the Stars, Radahn was once among the mightiest of the demi-gods, but like the rest fell from grace after warring with his family for control of the Great Runes
Lieutenant General Shepherd is a leader of the United States Army force in Afghanistan and Task Force 141 in Modern Warfare 2. He is voiced by Lance Henriksen.
A Cornian lord who joined Zenoira in his efforts to combat and cure the plague that took his wife.
Gilgamesh was the fifth king of Uruk. He is the central character in the Epic of Gilgamesh, which is the most complete piece of ancient Babylonian literature and mankind's oldest epic. He is the first mythological superhero in history.
Gollum was once a hobbit who rediscovered the ring of power and was corrupted by it's evil
Gordeau is a character from Under Night In-Birth.
A highschool student who moonlights as the "Detective Prince," helping Sae Niijima hunt down the Phantom Thieves.
The "God Butcher" of Marvel Comics, an alien with a grudge against deities.
A very large wolf who guards the grave of the once great Knight Artorias.
A tormented soul trapped in the body of a gargoyle, he is forced to serve Asmodeus against his will
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